SKU: 2845771231

Carbonic Anhydrase IX/CA9 His Tag Protein, Cynomolgus

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Description

Carbonic Anhydrase IX/CA9 His Tag Protein, CynomolgusProduct Specification Species Cynomolgus Synonyms Carbonate dehydratase IX, Carbonic anhydrase IX (CA IX; CAIX), Membrane antigen MN, P54 58N Accession A0A2K5VQG9 Amino Acid Sequence Gln38 Leu398, with C terminal His Expression System HEK293 Molecular Weight 40 50 kDa (Reducing) Purity 95% by SDS PAGE &95% by SEC HPLC Endotoxin <0. 1EU g Conjugation Unconjugated Tag His Tag Physical Appearance Lyophilized Powder Storage Buffer PBS, 5% trehalose, pH7.

Product Specification


Species Cynomolgus
Synonyms Carbonate dehydratase IX, Carbonic anhydrase IX (CA-IX; CAIX), Membrane antigen MN, P54/58N
Accession A0A2K5VQG9
Amino Acid Sequence Gln38-Leu398, with C-terminal His
Expression System HEK293
Molecular Weight

40-50 kDa (Reducing)

Purity >95% by SDS-PAGE &>95% by SEC-HPLC
Endotoxin <0.1EU/μg
Conjugation Unconjugated
Tag His Tag
Physical Appearance Lyophilized Powder
Storage Buffer PBS, 5% trehalose, pH7.4,
Reconstitution

Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.

Stability & Storage

· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.

· 3 months, -20 to -80℃ under sterile conditions after reconstitution.

· 1 week, 2 to 8℃ under sterile conditions after reconstitution.

· Please avoid repeated freeze-thaw cycles.

Reference

Supuran CT. Carbonic anhydrases: novel therapeutic applications for inhibitors and activators. Nat Rev Drug Discov 2008; 7:168-81.
McDonald PC, Swayampakula M, Dedhar S. Coordinated regulation of metabolic transporters and migration/invasion by carbonic anhydrase IX. Metabolites 2018;8: E20.

Background

The CAIX works as a dimeric molecule composed of two monomeric proteins liked with a disulfide bond between cysteine residues of the two CAIX monomers, while the structure of CAXII is stabilized by 19 hydrogen-bonded interactions in the dimer interface. Carbonic anhydrases IX and CAXII (CAIX/CAXII) are transmembrane zinc metalloproteins that catalyze a very basic but crucial physiological reaction: the conversion of carbon dioxide into bicarbonate with a release of the proton. CAIX functions with bicarbonate transporters (including electroneutral bicarbonate transporter NBCn1 (SLC4A7)) to bring in HCO3- produced in a CAIX-mediated hydration reaction of CO2, and amino acid transporters (including the large neutral amino acid transporter 1 (LAT1) and CD98 heavy chain (CD98hc)) to transport in essential amino acids and glutamine (via interaction with glutamine transporter SLC1A5 and sodium-coupled neutral amino acid transporter 2 (SNAT2) facilitating the uptake of amino acid by SLC1A5), which cancer cells employ as an alternative metabolic energy source and biosynthetic precursor. CAIX also creates unique interactions with collagen- and laminin-binding integrins at the leading edge of migrating cells.

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SKU: 2845771231

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Reviewed in the United States on May 25, 2025
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Perfect Travel Size TSA approved size
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I recently bought the Coppertone SPORT Sunscreen SPF 50 Lotion in travel size for my son’s first trip to Cancun alone, and I have to say, it was a fantastic choice! Whether you're headed to a sunny beach, a day of fishing, or just need reliable protection from the sun, this sunscreen delivers. Here’s my review based on its performance during the trip: Convenience and Travel-Friendly: The travel size is perfect for anyone on the go. It’s small enough to meet TSA guidelines for carry-ons, so you don’t have to worry about checking luggage or dealing with oversized bottles at security. My son was able to easily pack it in his carry-on without any hassle. Additionally, the compact size makes it super convenient to throw into a pocket or backpack for a day of fishing, beach trips, or any outdoor adventure. Sun Protection: The SPF 50 provides excellent protection from harmful UVA and UVB rays, which is especially important for long hours spent in the sun. Cancun’s sun can be intense, and my son was out in the elements for several hours each day (and I wasn't there to remind him to reapply sunscreen), whether he was fishing, swimming, or just relaxing at the beach. He didn’t get burned once!! As a mother of a redheaded 18 year old son I've spent the past 18 years of my life ensuring he wasn't scorched by the sun and Coppertone has yet to let us down! Water Resistance: The water-resistant formula is a huge plus, especially in places like Cancun, where you’ll likely be in and out of the water. My son spent plenty of time swimming and snorkeling, and the sunscreen stayed put. It lasted through sweating, splashing, and even sea water exposure without needing constant reapplication. It’s perfect for active outdoor activities, whether you're swimming, surfing, or just sweating it out in the sun. Mother approved!!
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Reviewed in the United States on November 9, 2024
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Linda NYC
Dallas, US
★★★★★ 5
Dries clear, moisturizing, silky, great value
Size: 5 Fl Oz (Pack of 1), Style: SPF 50
I have fair to light combination skin. I use this on my body, but not my face. It goes on very thick and white, but sinks into the skin lightning fast (within just a few seconds), and it becomes completely invisible. It leaves my skin moisturized and looking and feeling silky. Best body sunscreen I've ever tried. And I love that it is water resistant! I find it too heavy and moisturizing to use on my face, but people with dry skin would probably love it for the face, too. I imagine it would be fantastic for them under makeup. The price per ounce is very reasonable, making it a great value.
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Size: 5 Fl Oz (Pack of 1), Style: SPF 50
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